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. 2016 Aug 4;7:12307. doi: 10.1038/ncomms12307

Table 1. Comparison of crosstalk levels between the different variants of the model.

Model Crosstalk (at baseline parameters) Remarks
Basic model (activators-only) 0.23  
Basic model (repressors-only) 0.23  
Mixed model (activators+repressors) 0.14 2,000 genes expressed in 20% of the env., 3,000 genes in 70%
Genes of unequal importance 0.31 10% of the genes are important and penalized 10 × the ‘normal' rate
    The resulting error per important gene decreases to 0.1, but for the other genes increases to 0.33.
Unequal weights for the two error types 0.17 b=0.5, weight of erroneously active genes is half that of genes that are erroneously inactive
Each TF regulates exactly Θ=10 genes 0.08 Also holds for P(Θ)∼Poisson Inline graphic
Activators+global nonspecific repressor 0.23 Cannot reduce crosstalk
Activators+specific repressors (non-overlapping) 0.2  
Activators+specific repressors (overlapping) 0.15  
Perfect AND-gate combinatorial regulation 0.07 Uses only Inline graphic TF species
Generic cooperativity 0.064 For example, dimerization, direct TF–TF contacts, TF/nucleosome competition and so on. Two bindings sites, each of length L=10
Cooperativity exclusive to cognate binding 0.006 Currently unknown molecular mechanisms, two bindings sites, each of length L=10.

Baseline parameters are: Q=2,500, M=5,000, log(S)=−10.5—equivalent to a model where binding sites for distinct TFs are different from each other in at least 2 bp (dmin=2) with binding sites of L=10 bp and binding energy Inline graphic per mismatch.