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. 2016 Aug 8;7:245. doi: 10.3389/fphar.2016.00245

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Copyright © 2016 Banerjee, Chakraborty, Ghosh, Raha, Sen and Jana.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the molecular interplay of protective effect of curcumin and resveratrol against B(a)P induced testicular germ cell apoptosis. B(a)P enters the cell, associates with AhR and induces CYP1A1 promoter activity. B(a)P generates oxidative stress, activates MAPKs (ERK1/2,p38 MAPK,JNK1/2) and p53. B(a)P turns-on intrinsic and extrinsic apoptotic pathway in germ cells. Combinatorial treatment of curcumin and resveratrol prevent CYP1A1 production and quenches oxidative stress. They synergistically attenuate MAPK activation and p53 activation. Curcumin and resveratrol protect testicular germ cells from B(a)P induced apoptosis. B(a)P, Benzo(a)Pyrene; Cur, Curcumin; Res, Resveratrol.