. 2016 Feb 5;65(3):215–222. doi: 10.1538/expanim.15-0070

Table 1. Summary of right ventricular systolic pressure and echocardiographic parameters.

	2 week			4 week			6 week

	saline	MCT^a)	MCT/sildenafil	saline	MCT	MCT/sildenafil	saline	MCT	MCT/sildenafil
RVSP^b) mmHg	30.7 ± 4.8	33.2 ± 2.5	31.8 ± 1.6	28.0 ± 4.7	60.2 ± 14.9***	28.7 ± 1.8 ^†††	29.5 ± 2.7	60.7 ± 16.5***	29.8 ± 6.6^†††
HR^c) /min	357 ± 34	339 ± 48	300 ± 18***^†††	338 ± 42	325 ± 34	344 ± 60	334 ± 41	341 ± 28	281 ± 27***^†††
BW^d) g	309 ± 68	285 ± 77	253 ± 28	323 ± 33	329 ± 79	248 ± 8	358 ± 74	357 ± 97	248 ± 13**^†
EI^e)	0.88 ± 0.09	0.95 ± 0.14	0.98 ± 0.15	0.88 ± 0.1	1.28 ± 0.19***	0.99 ± 0.10^†††	0.91 ± 0.15	1.34 ± 0.43***	1.0 ± 0.09^†††
E/A^f)	0.99 ± 0.31	1.06 ± 0.33	0.88 ± 0.27	0.91 ± 0.32	0.95 ± 0.34	0.73 ± 0.26^†	0.76 ± 0.39	0.95 ± 0.28*	0.71 ± 0.14^††
E/Em^g)	6.76 ± 3.63	11.86 ± 4.59***	7.75 ± 1.53^†††	5.86 ± 1.53	8.09 ± 3.05	6.86 ± 2.25	6.53 ± 3.81	12.22 ± 7.73***	7.23 ± 1.52^†††
TAPSE^h) mm	2.6 ± 0.7	2.4 ± 0.6	1.5 ± 0.4*** ^†††	2.0 ± 0.8	1.4 ± 0.5**	1.6 ± 0.3	2.7 ± 1.0	1.4 ± 0.4***	1.8 ± 0.5***^†
Smⁱ⁾ cm/s	6.6 ± 1.2	5.4 ± 1.1**	6.0 ± 1.8	7.3 ± 2.2	6.0 ± 1.1**	6.5 ± 0.8	7.5 ± 1.6	5.0 ± 1.7***	6.0 ± 1.0**^†
TDI^j) Tei index	0.65 ± 0.21	0.82 ± 0.24**	0.42 ± 0.05***^†††	0.43 ± 0.19	0.64 ± 0.11***	0.43 ± 0.09^†††	0.62 ± 0.28	0.78 ± 0.36**	0.56 ± 0.11^†††

^a)MCT, Monocrotaline. ^b)RVSP, right ventricular systolic pressure. ^c)HR, heart rate. ^d)BW, body weight. ^e)EI, eccentricity index. ^f)E/A, the ratio of peak velocity of the early tricuspid inflow wave (E) to peak velocity of the late diastolic wave. ^g)E/Em, the ratio of trans-tricuspid early diastolic wave velocity to early diastolic myocardial velocity. ^h)TAPSE, tricuspid annular plane systolic excursion. ⁱ⁾Sm, systolic wave. ^j)TDI, tissue Doppler imaging. The data represent means ± SD; *P<0.05, ** P<0.01, *** P<0.001 vs. the saline group. ^†P<.05, ^††P<0.01, ^†††P<0.001 vs. the MCT group.