Table 1.
Demographic and Tumor Characteristics of University of Chicago Thyroid Cancer Cohort (n = 257)
| Radiation exposure (n = 92) | No radiation exposure (n = 165) | p | |
|---|---|---|---|
| Age at first thyroid surgery, years | 34.4 ± 13.6 | 36.7 ± 16.3 | 0.25 |
| Sex | 0.01 | ||
| Female | 52 (56.5%) | 120 (72.7%) | |
| Male | 40 (43.5%) | 45 (27.3%) | |
| Treatment | 0.88 | ||
| Total or near total | 60 (65.2%) | 106 (63.9%) | |
| Subtotal or lobectomy | 32 (34.8%) | 59 (36.1%) | |
| Radioactive iodine | 0.74 | ||
| Received | 46 (50%) | 86 (52.1%) | |
| Did not receive | 46 (50%) | 79 (47.9%) | |
| Histology (n = 104) | 0.83 | ||
| Classic papillary | 40 (93.1%) | 56 (91.8%) | |
| Follicular variant | 2 (4.6%) | 3 (4.8%) | |
| Columnar | 0 (0%) | 1 (1.6%) | |
| Follicular | 1 (2.3%) | 1 (1.6%) | |
| Multifocality | 0.89 | ||
| Unifocal | 51 (55.4%) | 93 (56.4%) | |
| Multifocal | 41 (44.6%) | 72 (43.6%) | |
| Lymph node involvement | 0.72 | ||
| 0 | 56 (60.9%) | 99 (60.0%) | |
| 1–5 | 20 (21.7%) | 42 (25.5%) | |
| >5 | 16 (17.4%) | 24 (14.5%) | |
| Extrathyroidal invasion | 36 (39.1%) | 56 (33.7%) | 0.39 |
| Stage | 0.10 | ||
| 1 | 83 (90.2%) | 127 (77.0%) | |
| 2 | 2 (2.2%) | 8 (4.8%) | |
| 3 | 1 (1.1%) | 7 (4.2%) | |
| 4a | 4 (4.3%) | 13 (7.9%) | |
| 4b | 2 (2.2%) | 10 (6.1%) | |
| Decade of diagnosis | 0.15 | ||
| Before 1960 | 10 (6.5%) | 12 (13.5%) | |
| 1960–1969 | 12 (7.8%) | 10 (11.2%) | |
| 1970–1979 | 74 (48.1%) | 42 (47.2%) | |
| After 1980 | 58 (37.7%) | 25 (28.1%) | |
| Primary treatment site | 0.12 | ||
| University of Chicago | 60 (65.2%) | 91 (55.2%) | |
| Other | 74 (44.9%) | 32 (34.8%) |