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Inhibition of murine myometrial contractions by pinacidil. (A) Pinacidil (5 µM) inhibited spontaneous contractions of murine longitudinal myometrium in a glibenclamide-sensitive manner. (B) Oxytocin (OXT, 10 nM) produced tri-phasic contractions, such as initial contractions, followed by tonic contractions overlapped with phasic contractions. Pinacidil inhibited OXT-induced phasic contractions to 12% of the control. Data are summarized in (C) and (D).
