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Prostaglandin F2α (PGF2α)-induced contractions were inhibited by K+ channel opening agents (KCOs). (A–D) PGF2α produced tri-phasic contractions, such as initial contractions, followed by tonic contractions overlapped with phasic contractions. PGF2α-induced phasic contractions were inhibited by pinacidil, diazoxide, cromakalim and nicorandil.
