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. 2016 May 12;23(8-9):673–679. doi: 10.1038/gt.2016.40

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Morphometric and histological analysis of hearts from mice treated with AAV-DES compared with AAV-LUC and wild-type controls. (a) Heart weight to tibia length ratios are significantly decreased in AAV-DES-treated animals (n=10) when compared with AAV-LUC controls (n=9) or wild-type mice (n=12). (b) Ventricular fibrosis is also significantly decreased in AAV-DES (n=10) and wild type (n=12) when compared with AAV-LUC (n=10). (c–e) Representative Masson's trichrome stainings of the left ventricle of AAV-LUC (n=10) (c), AAV-DES (n=10) (d) and wild type (n=12) (e). Note the intense fibrotic area (blue) depicted in (c). *P<0.05, **P<0.01.