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. 2016 May 12;23(8-9):673–679. doi: 10.1038/gt.2016.40

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Follow-up echocardiography. Mice were injected at the age of 2 months following baseline echocardiography. (a) Systolic left-ventricular (LV) function was significantly reduced in the AAV-LUC group (n=9) after 12 months in comparison with AAV-DES-treated knockout mice (n=10). (b) LV end-diastolic diameter in the AAV-LUC group was significantly increased when compared with WT (n=12) controls, while no significant differences were detectable between the AAV-DES group and WT controls (P=0.7). *P<0.05, ***P<0.001. † premature death of an AAV-LUC animal.