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. 2016 Aug 8;6:29864. doi: 10.1038/srep29864

Figure 3. DCE-MRI Detects Dose-Dependent Vascularity Changes During EBRT.

Figure 3

(A) Composite histogram of DCE-MRI acquired Ktrans values across the entire mandibular region of interest (ROI). Ktrans analysis was performed on a voxel-wise basis across the entire mandibular ROI and at specific EBRT doses for each patient. The figures depict the voxel-wise mean S ΔKtrans by dose trajectories estimated at two time points using cubic spline analysis. Red (blue) lines indicate patients which demonstrate a dose-dependent increase (decrease) in mean S ΔKtrans from pre-treatment values. Grey lines represent patients without a dose-dependent change in mean S ΔKtrans. (B) Heatmap with color indicating the extent of vascular modulation and corresponding mean S ΔKtrans trajectories demonstrating a stable Ktrans value set across the irradiation period regardless of dose. (C) Heatmap and S ΔKtrans trajectories demonstrating a dose-dependent increase in Ktrans value set across the irradiation period. (D) Heatmap and S ΔKtrans trajectories demonstrating a dose-dependent decrease in Ktrans value set across the irradiation period. (E) Composite histogram of DCE-MRI acquired Ve values across the entire mandibular region of interest (ROI). Ve analysis was performed on a voxel-wise basis across the entire mandibular ROI and at specific EBRT doses for each patient. The figures depict the voxel-wise mean S ΔVes by dose trajectories estimated at two time points using cubic spline analysis. Red (blue) lines indicate patients which demonstrate a dose-dependent increase (decrease) in mean S ΔVe from pre-treatment values. Grey lines represent patients without a dose-dependent change in mean S ΔVe. (F) Heatmap with color indicating the extent of vascular modulation and corresponding mean S ΔVe trajectories demonstrating a stable Ve value set across the irradiation period regardless of dose. (G) Heatmap and S ΔVe trajectories demonstrating a dose-dependent increase in Ve value set across the irradiation period. (H) Heatmap and S ΔVe trajectories demonstrating a dose-dependent decrease in Ve value set across the irradiation period. MID-PRE = change across EBRT dose between PRE-irradiation scan and MID-irradiation scan. POST-PRE = change across EBRT dose between PRE-irradiation scan and POST-irradiation scan.