TABLE 2.
Interlaboratory agreement for caspofungin susceptibility data with 30 isolates of Candida spp.a
| Test conditions | Endpoint | Visual readings
|
Spectrophotometer results
|
||
|---|---|---|---|---|---|
| Agreement range (%) | Excellent agreement (%) | Agreement range (%) | Excellent agreement (%) | ||
| RPMI, 24 h | MIC0 or IC90 | 37.5-100.0 | 33.3 | 36.6-93.3 | 3.3 |
| MIC2 or IC50 | 64.7-100.0 | 73.3 | 26.6-100.0 | 53.3 | |
| RPMI, 48 h | MIC0 or IC90 | 44.1-100.0 | 36.7 | 33.3-86.7 | 0.0 |
| MIC2 or IC50 | 26.4-100.0 | 43.3 | 40.0-96.7 | 20.0 | |
| RP-G, 103 yeasts/ml, 24 h | MIC0 or IC90 | 29.4-94.1 | 20.0 | 33.3-100.0 | 16.7 |
| MIC2 or IC50 | 53.1-97.0 | 50.0 | 40.0-100.0 | 53.3 | |
| RP-G, 103 yeasts/ml, 48 h | MIC0 or IC90 | 41.1-94.1 | 40.0 | 26.6-90.0 | 10.0 |
| MIC2 or IC50 | 38.2-100.0 | 26.7 | 36.6-96.7 | 36.7 | |
| RP-G, 105 yeasts/ml, 24 h | MIC0 or IC90 | 38.2-100.0 | 36.7 | 30.0-100.0 | 20.0 |
| MIC2 or IC50 | 41.1-94.1 | 26.7 | 53.3-100.0 | 40.0 | |
| RP-G, 105 yeasts/ml, 48 h | MIC0 or IC90 | 35.2-100.0 | 60.0 | 46.6-96.7 | 16.7 |
| MIC2 or IC50 | 40.6-100.0 | 16.7 | 30.0-100.0 | 30.0 | |
| AM3, 24 h | MIC0 or IC90 | 56.2-100.0 | 50.0 | 40.0-92.9 | 6.7 |
| MIC2 or IC50 | 43.7-100.0 | 60.0 | 42.8-93.3 | 33.3 | |
| AM3, 48 h | MIC0 or IC90 | 48.3-100.0 | 40.0 | 43.3-96.7 | 6.7 |
| MIC2 or IC50 | 18.7-100.0 | 56.7 | 20.0-96.7 | 16.7 | |
a
Agreement range, percentage of results within excellent agreement range across all 30 isolates; excellent agreement, percentage of isolates with ≥90% interlaboratory agreement.