TABLE 3.
Percentages of MIC2 or IC50 results recorded in 17 laboratories for 8 Candida spp. isolates with known low susceptibility to caspofungin and 22 isolates with normal susceptibility
| Caspofungin concn (μg/ml) | % MIC2 or IC50a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| RPMI (MIC2)
|
RPMI (IC50)
|
AM3 (MIC2)
|
AM3 (IC50)
|
|||||
| Normal (n = 739) | Low (n = 265) | Normal (n = 535) | Low (n = 193) | Normal (n = 733) | Low (n = 270) | Normal (n = 513) | Low (n = 198) | |
| 0.008 | 0.0 | 0.0 | 0.0 | 0.0 | 56.5 | 6.7 | 71.2 | 8.6 |
| 0.016 | 0.0 | 0.0 | 0.0 | 0.0 | 8.9 | 0.4 | 9.6 | 2.5 |
| 0.032 | 4.6 | 0.4 | 9.3 | 3.6 | 22.0 | 1.5 | 11.1 | 2.5 |
| 0.063 | 21.2 | 0.0 | 26.5 | 1.6 | 7.6 | 1.9 | 5.8 | 2.5 |
| 0.13 | 20.7 | 0.0 | 23.6 | 5.7 | 2.7 | 3.3 | 0.4 | 5.1 |
| 0.25 | 18.4 | 1.9 | 18.1 | 2.1 | 0.5 | 7.4 | 0.0 | 4.5 |
| 0.5 | 21.1 | 2.3 | 14.6 | 3.6 | 0.1 | 21.5 | 0.4 | 15.2 |
| 1 | 11.1 | 14.0 | 6.5 | 13.5 | 0.0 | 28.1 | 0.0 | 33.3 |
| 2 | 1.8 | 46.8 | 1.1 | 37.8 | 0.0 | 17.8 | 0.0 | 15.7 |
| 4 | 0.0 | 25.3 | 0.0 | 20.2 | 0.0 | 6.7 | 0.0 | 6.1 |
| 8 | 0.1 | 4.5 | 0.0 | 5.7 | 0.0 | 0.7 | 0.2 | 2.0 |
| 16 | 0.5 | 2.3 | 0.2 | 4.7 | 1.6 | 4.1 | 1.4 | 2.0 |
| 32 | 0.4 | 1.5 | 0.0 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| >32 | 0.0 | 1.1 | 0.0 | 0.5 | 0.0 | 0.0 | 0.0 | 0.0 |
a
n = the number of results from 17 laboratories. The χ2 values for RPMI (MIC2), RPMI (IC50), AM3 (MIC2), and AM3 (IC50) were 727, 467, 784, and 529, respectively.