TABLE 3.
Incidence of HPV-positive cases as determined by ISH, conventional PCR, and real-time PCR
| Method and HPV type(s) | No. of HPV-positive samples/ total no. of samples (%) in:
|
P | |
|---|---|---|---|
| 1989-1994 | 1995-2000 | ||
| ISH | |||
| HPV6/11 | 3/65 (4.6) | 15/79 (19) | 0.011 |
| HPV16/18 | 19/66 (28.8) | 45/82 (54.9) | 0.002 |
| HPV31/33/51 | 5/64 (7.8) | 19/79 (24.1) | 0.013 |
| All HPV types | 19/63 (24.7) | 47/77 (61.0) | <0.0001 |
| Conventional PCR | |||
| HPV16 | 33/71 (46.5) | 69/87 (79.3) | <0.0001 |
| HPV18 | 10/74 (13.5) | 26/87 (29.9) | 0.014 |
| HPV16/18 | 41/71 (57.7) | 76/87 (87.4) | <0.0001 |
| HPV consensus | 8/42 (19) | 45/81 (55.6) | <0.0001 |
| Real-time PCR | |||
| HPV16 | 36/74 (48.6) | 63/87 (72.4) | 0.003 |
| HPV18 | 11/74 (14.9) | 23/87 (26.4) | 0.083 |
| HPV16/18 | 47/74 (63.5) | 78/87 (89.7) | <0.0001 |