TABLE 3.

Factors predictive of distant recurrence-free probability (DRFP) in multivariable analysis

Variable	HR	95 % CI	p Value
Clinical model (4 variables)
cT stage (1, 2, 3 vs. 4)	4.0	2–8	<0.001
cN stage (N0 vs. N+)	2.85	1.4–5.79	0.004
Gender (female vs. male)	2.1	1.13–5.79	0.018
Age (continuous)	1.01	0.99–1.03	0.411
Pathologic model (4 variables)
Pathology grade (low/intermediate     vs. high)	7.54	1.71–33.35	0.008
Perineural invasion	5.04	1.65–15.42	0.005
pT stage(1, 2, 3 vs. 4)	1.28	0.59–2.77	0.539
pN (N0/Nx vs. N+)	3.45	1.55–7.66	0.002

HR hazard ratio, CI confidence interval