TABLE 3.

Factors predictive of overall, disease-specific, and recurrence-free survival.

	OS				DSS				RFS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
Variables	5-y OS (%)	p value	RR (95) CI)	p value	5-y DSS (%)	p value	RR (95) CI)	p value	5-y RFS (%)	p value	RR (95) CI)	p value
Age, y
<60	76		Referent		88				85
>60	39	.0001	1.8 (0.8–3.8)	.15	60	.056	–		67	.07	–
Sex
Male	72				86				71
Female	49	.04	–		69	.065	–		83	.52	–
Smoking
Never	69				83				83
Ever	65	.73	–		84	.25	–		82	.63	–
Alcohol
Never	88				100				100
Ever	58	.15	–		77	.12	–		75	.15	–
Clinical T classification
cT1	76				100				100
cT2	78				83				83
cT3	59				75				68
cT4	38	.02	–		58	.108	–		66	.05	–
Clinical N classification
cN0	61				77				78
cN1	60				75				72
cN2	70				87				85
cN3	0	.54	–		100	.62	–		100	.78	–
Pathologic T classification
pT1	81		Referent		92		–		88
pT2	70		1.5 (0.6–3.5)	.4	78				79
pT3	40		3.2 (0.8–12.9)	.09	50				50
pT4	37	.006	2.5 (0.9–6.8)	.07	69	.36	–		75		.13	–
Pathologic N classification
pN0	60				80				75
pN1	73				82				81
pN2	66	.93	–		83	.822	–		81	.8	–
Grade
Well differentiated	67				100				100
Moderately differentiated	57				81				79
Poorly differentiated	74	.88	–		84	.46	–		82	.86	–
Margin status
Negative	78		Referent		89				83
Close/positive	52	.01	1.5 (0.7–3.2)	.27	72	.07	–		74	.32	–
Necrosis
Present	62				72				75
Absent	66	.76	–		83	.42	–		81	.08	–
LVI
Present	23		2.4 (1–5.4)	.04	43		6.9 (1.9–25.3)	.003	37		5.5 (1.9–16.1)	.002
Absent	73	.0001	Referent		89	.0001	Referent		88	.0001	Referent
PNI
Present	50				71				83		1.5 (0.5–4.7)	.46
Absent	68	.22	–		83	.25	–		83	.07	Referent
ECS (n 5 68)
Positive	51				69		2.7 (0.7–11.2)	.16	71
Negative	79	.2	–		93	.03	Referent		90	.15	–
ECS, all
Positive	51				89				71
Negative	72	.3	–		88	.05	–		85	.28	–
p16 status
Positive	74				89				87
Negative	47	.04	–		66	.08			73	.48

Abbreviations: OS, overall survival; DSS, disease-specific survival; RFS, recurrence-free survival; RR, risk ratio; CI, confidence interval; LVI, lymphovascular invasion; PNI, perineural invasion; ECS, extracapsular spread.

The figures in bold indicate statistical significance.