Table 3.

Disease characteristics

Disease characteristics	Everolimus N  =  120
Time since TSC diagnosis, median (range), years	9.1 (0.2–30.7)
Time since SEGA diagnosis, median (range), years	3.8 (0–24)
Modified Gomez criteria - major features, n (%)
Facial angiofibromas or forehead plaques	93 (77.5)
Non-traumatic ungual or periungual fibroma	18 (15.0)
Hypomelanotic macules (3 or more)	95 (79.2)
Shagreen patch (connective tissue nevus)	47 (39.2)
Multiple retinal nodular hamartomas	23 (19.2)
Cortical tuber	106 (88.3)
Subependymal nodule	102 (85.0)
Subependymal giant cell astrocytoma	120 (100.0)
Cardiac rhabdomyoma, single or multiple	55 (45.8)
Lymphangioleiomyomatosis	2 (1.7)
Renal angiomyolipoma	59 (49.2)
Modified Gomez criteria - minor features, n (%)
Multiple, randomly distributed pits in dental enamel	6 (5.0)
Hamartomatous rectal polyps	0 (0.0)
Bone cysts	2 (1.7)
Cerebral white matter radial migration lines	16 (13.3)
Gingival fibromas	6 (5.0)
Non-renal hamartoma	3 (2.5)
Retinal achromic patch	4 (3.3)
'Confetti' skin lesions	15 (12.5)
Multiple renal cysts	19 (15.8)

SEGA subependymal giant cell astrocytoma, TSC tuberous sclerosis complex