Table 1.
Distribution of Covariates Stratified by BMI and the Presence of Diabetes Mellitus
| Non-Diabetics (n=65) | Diabetics N=33 | Overall Comparison | Other Comparisons | |||
|---|---|---|---|---|---|---|
| Variable | Obese | Non-Obese | Obese | Non-Obese | P-value | P-value |
| Demographics | ||||||
| Age (years) | 44 ± 11 | 47 ± 13 | 55 ± 12 | 54 ± 12 | 0.02 | A |
| Males (%) | 63 | 82 | 43 | 67 | R | |
| Clinical Characteristics | ||||||
| KT/V | 1.5 ± 0.2 | 1.6 ± 0.2 | 1.6 ± 0.3 | 1.6 ± 0.2 | 0.2 | |
| Albumin (g/dL) | 4 (3.9, 4.3) | 4 (3.8, 4.3) | 3.9 (3.6, 4) | 3.9 (3.6, 4.2) | 0.2 | A |
| Prealbumin (mg/dL) | 40 (33, 47) | 39 (30, 47) | 36 (30, 40) | 34 (27, 42) | 0.3 | |
| Creatinine (mg/dL) | 10.3 ± 2.9 | 8.8 ± 2.8 | 7.4 ± 2.6 | 8.2 ± 2.9 | 0.1 | A,C |
| Intact PTH (pg/mL) | 446 (272, 842) | 344 (191, 470) | 355 (260, 684) | 470 (240, 835) | 0.3 | |
| Bicarbonate (mg/dL) | 25 ± 4 | 25 ± 4 | 25 ± 4 | 27 ± 4 | 0.3 | |
| Metabolic Biomarkers | ||||||
| hsCRP (mg/dL) | 9.3 (5.7,14.8) | 3.9 (2.2, 8.6) | 13.2 (4.9, 17.65) | 6.75 (5.2, 18) | 0.01 | A,B,C |
| Interleukin-6 (pg/ml) | 6.2 (4.5, 16.3) | 5.4 (2.8, 13.7) | 14 (8.9, 18.5) | 9.8 (6.7, 16.9) | 0.08 | A, C |
| Protein thiols (μmol/mL) | 280 ± 59 | 254 ± 19 | 230 ± 36 | 196 ± 10* | 0.03 | A,C |
| Leptin (ng/ml) | 50.3 (16.4, 71.51) | 6.4 (2.68, 9.9) | 67.4 (20.9, 99.6) | 12.8 (6.3, 21.31) | 0.001 | B |
| Adiponectin (μg/ml) | 12 (8.3, 23.3) | 37.7 (23.7, 57.4) | 40.2 (18.8, 61.6) | 16.55 (9.8, 90.3) | 0.001 | B |
| Body Composition | ||||||
| BMI (kg/m2) | 36 ±4.8 | 24 ± 2.7 | 39 ± 7.0 | 27 ± 1.8 | 0.001 | A,B,C |
| Truncal Tissue Fat (%) | 46.3 ± 0.1 | 28.4 ± 11.1 | 45 ± 0.1 | 33.2 ± 0.1 | 0.001 | B |
| LBM (kg) | 56.5 ±12.1 | 48.7 ± 7.8 | 54.5 ± 13.8 | 50.1 ± 8.5 | 0.04 | B |
A
Statistically significant difference between diabetic vs. non diabetic patients
B
Statistically significant difference between obese vs. non-obese patients.
C
Statistically significant difference between diabetic obese vs. non-diabetic obese patients
• PTH, parathyroid hormone; BMI, Body Mass Index
There were only 3 patients with protein thiol measurements in the diabetic non obese patients