. Author manuscript; available in PMC: 2016 Aug 8.

Published in final edited form as: Obesity (Silver Spring). 2009 Jun 11;17(12):2190–2195. doi: 10.1038/oby.2009.181

Table 2.

Linkage analysis results on chromosome 2p25 in the NHLBI FHS

Sample and adjustment	Complete data	Nonmedicated data^a
Sample and adjustment	Basic^b	Basic^b	Extended^c
BMI
Overall additive genetic heritability	0.43 ± 0.04	0.44 ± 0.04	0.48 ± 0.04
Lod (location)	1.59 (18 cM)	2.43 (15 cM)	4.31 (13 cM)
P value	0.00343	0.00041	0.0000042
FDR P value	0.02366	0.00453	0.0000512
WC
Overall additive genetic heritability	0.41 ± 0.04	0.42 ± 0.04	0.45 ± 0.04
Lod (location)	1.32 (18 cM)	2.26 (16 cM)	4.23 (13 cM)
P value	0.00677	0.00063	0.0000050
FDR P value	0.03187	0.00559	0.0000568

FDR, false discovery rate; NHLBI FHS, National Heart, Lung, and Blood Institute Family Heart Study; WC, waist circumference.

Nonmedicated data: subjects taking medications high cholesterol and/or diabetes were excluded.

Basic adjustment: age, field centers, and sex.

Extended adjustment: age, field centers, sex, lipid–lipoprotein levels, and dietary intake factors.