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. 2015 Oct 19;36(8):1374–1383. doi: 10.1177/0271678X15610786

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© The Author(s) 2015

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — miR-122 mimic down-regulates genes in blood after MCAO in rats. Scrambled miRNA mimic and miR-122 mimic were wrapped using PEG-liposomes prior to intravenous administration after MCAO. Upper left panel: miR-122 direct target genes down regulated 24 h following MCAO which have sequences complementary to miR-122. Upper right panel: miR-122 indirect target genes down-regulated 24 h following MCAO. The indirect target genes shown are known to be regulated by Vcam1 and/or Nos2- which are direct miR-122 target genes. Middle panel: top 5 ranked canonical pathways of the miR-122 direct and indirect target genes that were down-regulated by miR-122 mimic 24h following MCAO. Lower panel: these are mRNAs that were down regulated 24 h following miR-122 treatment. These genes are not known to be either direct or indirect miR-122 targets. Thus, these represent novel miR-122 indirect target genes that must be regulated by one of the known miR-122 direct target genes. There are two colors of the lined circles in upper and lower panels: (1) the red lined circled genes were deceased greater than three times; and (2) the black lined circled genes were decreased ranging from 1.4 through three times. In addition, there are three thicknesses of the lined circles in upper and lower panels: (1) the small thickness lined circled genes were decreased with p > 0.05; (2) the medium thickness lined circled genes were decreased with 0.01 < p < 0.05; and (3) the large thickness lined circled genes were decreased with p < 0.01. (n = 6/group).