Table 2.
Potassium Binding by Protonated Polymers Under Conditions Mimicking Large Intestine pH and Residence Time.
| Polymer (4 mg/mL) | Potassium Bounda (mEq/g) (Mean ± SD) | Final pHb (Mean ± SD) |
|---|---|---|
| Experiment 1 (N = 3) | ||
| RLY5016Hc | 8.53 ± 0.13 | 6.21 ± 0.02 |
| Amberlite IRP-64H | 3.62 ± 0.28 | 6.42 ± 0.02 |
| Polystyrene sulfonate H | 5.09 ± 0.05 | 6.35 ± 0.02 |
| Dowex 50WX4 | 5.25 ± 0.11 | 6.34 ± 0.02 |
| Experiment 2 (N = 3) | ||
| RLY5016Hc | 8.77 ± 0.35 | 6.23 ± 0.01 |
| Amberlite IRP-64H | 3.75 ± 0.05 | 6.43 ± 0.02 |
| Polystyrene sulfonate H | 4.80 ± 0.3 | 6.36 ± 0.01 |
| Dowex 50WX4 | 4.97 ± 0.03 | 6.35 ± 0.02 |
Abbreviation: SD, standard deviation.
aPotassium (K) bound to the test polymers (mEq/g) was calculated as (Kstart − Keq) × dilution factor/polymer concentration, where Kstart is the potassium ion concentration (mmol/L) measured in the diluted control sample, and Keq is the potassium ion concentration (mmol/L) in the diluted test samples after incubation with polymer.
bStarting pH was 6.5.
cRLY5016H is the protonated form of RLY5016.