Figure 6.

(a–c) Extracellular levels of risperidone and its metabolite (9-hydroxyrisperidone or paliperidone) in the brains of female WT mice (black circles) and HD transgenic mice (white circles) receiving an intraperitoneal (i.p.) administration of 3 mg/kg risperidone (a and b) or paliperidone (c). (d) Effects of tariquidar (TQD) treatment (6 mg/kg, single intravenous injection) on brain extracellular levels of risperidone in male WT and HD mice receiving an i.p. administration of 3 mg/kg risperidone. The data are presented as the mean ± SEM of 3–6 mice.