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. 2016 Jul 29;22:2679–2684. doi: 10.12659/MSM.898111

Figure 1.

Figure 1

Effects of lipopolysaccharide (LPS) and transient receptor potential canonical (TRPC) blockers on neointima formation of rat pulmonary arteries and proliferation of pulmonary arterial smooth muscle cells (PASMCs). (A) Frozen sections of pulmonary arteries after culturing for 27 days without/with LPS (10 μg/mL), 2-aminoethoxydiphenyl borate (2-APB; 100 μM), and SKF-96365 (100 μM). Scale bar: 0.1 mm. (B) Ratio between the areas of neointima and media and percentage of decreased luminal area (stenosis) in the arterial sections. ** P<0.01 vs. control group; ## P<0.01; ### P<0.001 vs. LPS group; n=5 in each group. (C) Result of WST assay on PASMCs. 2-APB and SKF-96365 at 100 μM were used. ** P<0.01; *** P<0.001 vs. LPS 0 control; ### P<0.001 vs. corresponding columns in the control group; n=8 in each column.