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. Author manuscript; available in PMC: 2016 Aug 8.
Published in final edited form as: J Neuroendocrinol. 2010 Apr 6;22(8):862–871. doi: 10.1111/j.1365-2826.2010.02004.x

Table 2.

Mean ± SEM of pulsar Parameters Measurements of Treated Rats During 13.00–05.00 h of the Sampling Period.

Vehicle 40% Corticosterone 100% Corticosterone
AUC 3491 ± 1124 1747 ± 317 13016 ± 2858
Mean corticosterone (ng/ml)   47.2 ± 14.0   22.4 ± 4.4*   240.8 ± 65.2
Pulse number     5.8 ± 0.6     3.7 ± 1.4       8.5 ± 1.4
Pulse amplitude (ng/ml)   74.7 ± 19.2   35.6 ± 11.1   165.5 ± 51.0
Pulse height (ng/ml)   91.3 ± 20.1   49.1 ± 11.3*   337.0 ± 78.3
Pulse frequency (pulse/h)   0.59 ± 0.06   0.39 ± 0.13     0.92 ± 0.11

Pellets from rats previously treated for 7 days with vehicle (n = 4), 40% (n = 6) or 100% corticosterone pellets (n = 6) were removed in the morning of post–surgery day 8. pulsar analysis only demonstrates significantly lower mean corticosterone concentrations and pulse height (*P < 0.05) in animals treated with 40% corticosterone pellets compared to vehicle as indicated by independent Student’s t-tests. AUC, area under the curve.