Table 1. Summary of hit molecular scaffolds identified by the HT-CM-SPR of hTau^2N4Rwt.

Series	Series Eponym	Number of Hits	Affinity in HT-CM-SPRa
1	phenoxy-acetamides	10	weak
2	benzimidazoles	6	weak
3	sulfonamides	6	weak
4	ureas	5	weak
5	carboxylic acids	7	medium
6	tetrazoles	3	weak
7	triazines	9	medium
8	mesyl-phenyl-oxo-butyramides	4	weak
9	cyano-benzamides	4	weak
10	piperidinyl-methylfuran-carboxamides	4	weak
11	structurally unrelated fragments	19	weak
12	structurally unrelated lead-like compounds	41	weak-medium

^aAverage relative affinity of immobilized hits to hTau^2N4Rwt detected by SPR in the HT-CM-SPR.