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. 2015 Sep;12(9):814–828. doi: 10.2174/156720501209151019104951

Table 3. Ranges of selected physicochemical properties for the 118 hits identified by the HT-CM-SPR of full length hTau2N4Rwt as well as for the 70 resynthesized compounds.

118 Linked
Array Hits
70 Compounds
Resynthesized
Min Mean Median Max Min Mean Median Max
MW 209.2 350.8 344.9 539.6 223.2 346.8 344.4 528.5
ClogP -2.32 1.76 2.07 4.21 -0.87 1.69 1.89 4.21
#ACCEPTORS 2 4.3 4 9 2 3.9 4 6
#DONORS 1 2.9 3 8 1 2.6 3 6
#ROTBONDS 2 6.1 6 12 2 5.6 6 11
#RINGCOUNT 1 2.7 3 4 1 2.7 3 4
HAC 15 24.9 25 38 16 24.8 25 38
TPSA 35.6 95.7 89.8 200.9 35.6 87.5 81.3 157.9