Table 3. Ranges of selected physicochemical properties for the 118 hits identified by the HT-CM-SPR of full length hTau2N4Rwt as well as for the 70 resynthesized compounds.
118 Linked
Array Hits |
70 Compounds
Resynthesized |
|||||||
---|---|---|---|---|---|---|---|---|
Min | Mean | Median | Max | Min | Mean | Median | Max | |
MW | 209.2 | 350.8 | 344.9 | 539.6 | 223.2 | 346.8 | 344.4 | 528.5 |
ClogP | -2.32 | 1.76 | 2.07 | 4.21 | -0.87 | 1.69 | 1.89 | 4.21 |
#ACCEPTORS | 2 | 4.3 | 4 | 9 | 2 | 3.9 | 4 | 6 |
#DONORS | 1 | 2.9 | 3 | 8 | 1 | 2.6 | 3 | 6 |
#ROTBONDS | 2 | 6.1 | 6 | 12 | 2 | 5.6 | 6 | 11 |
#RINGCOUNT | 1 | 2.7 | 3 | 4 | 1 | 2.7 | 3 | 4 |
HAC | 15 | 24.9 | 25 | 38 | 16 | 24.8 | 25 | 38 |
TPSA | 35.6 | 95.7 | 89.8 | 200.9 | 35.6 | 87.5 | 81.3 | 157.9 |