Table 5.
Multiple logistic regression analysis of clinical factors and comorbidities associated with frequent severe acute exacerbations during 1-year of follow-up and early frequent severe acute exacerbations during 90 days of follow-up
| Adjusted odds ratio | 95% confidence interval | P-value | |
|---|---|---|---|
| Factors associated with frequent severe AEs during 1-year of follow-upa | |||
| Asthma | 4.02 | 1.30–12.46 | 0.016 |
| Home oxygen therapyb | 9.39 | 1.60–55.30 | 0.013 |
| CRP | 1.09 | 1.01–1.19 | 0.036 |
| Factors associated with early frequent severe AEs during 90 days of follow-upa | |||
| FEV1, L | 0.16 | 0.04–0.70 | 0.015 |
Notes:
a
Adjusted for age, sex, asthma, ischemic heart disease, congestive heart failure, FEV1 (L), CRP, home oxygen therapy, and long-term oral steroid.
b
Unstable due to the fact that only two of nine patients who used home oxygen therapy did not develop AE.
Abbreviations: AE, acute exacerbation; CRP, C-reactive protein; FEV1, forced expiratory volume in 1 second.