Table 1.
Baseline characteristics and treatment outcomes between patients with and without progression to HCC
| Variable | Total (n=105) | Without progression to HCC (n=90) | Progression to HCC (n=15) | P-value |
|---|---|---|---|---|
| Follow-up time, yearsa | 4.4±1.7 | 4.4±1.7 | 4.8±2.0 | 0.392 |
| Age, yearsa | 58.3±10.4 | 57.4±10.7 | 63.5±5.7 | 0.028* |
| Male, n (%) | 47 (44.8) | 41 (45.6) | 6 (40.0) | 0.783 |
| SVR, n (%) | 57 (54.3) | 54 (60.0) | 3 (20.0) | 0.005* |
| DM, n (%) | 28 (26.7) | 24 (26.7) | 4 (26.7) | 1.000 |
| Cohepatitis, n (%)b | 51 (48.6) | 46 (51.1) | 5 (33.3) | 0.268 |
| HBV coinfection, n (%) | 10 (9.5) | 9 (10) | 1 (6.7) | 1.000 |
| Fatty liver, n (%) | 44 (41.9) | 39 (43.3) | 5 (33.3) | 0.577 |
| Alcoholism, n (%) | 10 (9.5) | 10 (11.1) | 0 (0) | 0.351 |
| Genotype 1, n (%) | 66 (62.9) | 57 (86.4) | 9 (13.6) | 0.782 |
| High RNA load, n (%)c | 76 (72.4) | 66 (73.3) | 10 (66.7) | 0.756 |
| APRIa | 2.4±1.6 | 2.2±1.4 | 4.1±2.0 | 0.001* |
| ALTa | 122.9±81.7 | 117.9±84.3 | 153.3±57.2 | 0.014* |
| ASTa | 93.2±51.4 | 87.6±50.3 | 127.0±46.5 | 0.002* |
| Plateleta | 124.4±49.2 | 129.1±50.9 | 96.5±22.8 | 0.017* |
| AFPa | 16.6±23.2 | 16.2±23.9 | 19.0±18.9 | 0.233 |
| Albumina | 4.0±0.4 | 4.0±0.4 | 3.9±0.3 | 0.179 |
| PT/INRa | 1.1±0.1 | 1.1±0.1 | 1.1±0.1 | 0.762 |
| Total bilirubina | 0.9±0.4 | 0.9±0.3 | 1.1±0.5 | 0.182 |
Notes:
Data are expressed as mean ± standard deviation;
cohepatitis includes hepatitis B coinfection, alcoholism, or fatty liver;
the cutoff value for discriminating low and high baseline HCV RNA is 400,000 IU/mL. Student’s t-test and the Mann–Whitney U-test were used to compare continuous variables. The Fisher’s exact test was used to compare the categorical variables.
P<0.05.
Abbreviations: SVR, sustained virologic response; DM, diabetes mellitus; APRI, aspartate aminotransferase to platelet ratio index; HCC, hepatocellular carcinoma; HBV, hepatitis B virus; PT/INR, international normalized ratio of prothrombin time; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HCV, hepatitis C virus.