Table 2. . Binding affinity at dopamine transporter, serotonin transporter and norepinephrine transporter in rat brain.

Compound	[3H]DA† uptake	[3H]5-HT† uptake Ki (nM)	[3H]DA† uptake
D-185‡	62.4 ± 5.6	16.1 ± 1.6	12.6 ± 3.7
D-411§	15.9 ± 1.7	12.9 ± 1.3	29.3 ± 4.8
D-161‡	42.0 ± 3.3	29.1 ± 3.5	30.5 ± 7.8
D-142§	37.4 ± 3.9	14.7 ± 2.1	29.3 ± 7.9
D-199¶	34.6 ± 6.5	19.9 ± 1.5	54.3 ± 9.8
D-391§	31.3 ± 10.6	40.1 ± 4.9	38.5 ± 6.0
D-471‡	38.4 ± 2.6	58.4 ± 4.0	4.20 ± 2.3
D-478‡	11.2 ± 2.8	3.0 ± 0.3	6.1 ± 2.4
D-451‡	32.5 ± 4.3	69.1 ± 19.8	8.4 ± 1.7
D-168‡	85.2 ± 8.2	25.0 ± 8.4	25.5 ± 9.6
D-473#	70.4 ± 16.7	9.18 ± 1.69	39.7 ± 7.6
Fluoxetine	1092 ± 98	12.2 ± 2.4	158 ± 58
Reboxetine	>10,000	503 ± 61	0.69 ± 0.21

^†For uptake by DAT, SERT and NET, [³H]DA, [³H]5-HT and [³H]NE accumulation were measured. Results are average ± SEM of three to eight independent experiments assayed in triplicate.

^‡See [98].

^§See [99].

^¶See [96].

^#Uptake into cells expressing human DAT, SERT and NET [100].