Table 1. . KATP channel modulators .

Compound	Structure	Selectivity	IC50/EC50	Ref.
Inhibitors
Tolbutamide		SURl >SUR2	2–7 μM	[16,17]
Glibenclamide (glyburide)		SUR1 >SUR2A	SUR1 ˜4 nM SUR2A ˜27 nM	[16]
Gliclazide		SURl	˜50 nM	[18]
Glipizide		SUR1	4 nM	[19]
Mitiglinide		SURl ˜ SUR2	SUR1 ˜0.3 μM SUR2A ˜0.5 μM	[20]
Nateglinide		SUR1 ˜SUR2B >> SUR2A	SUR1 ˜SUR2B 100 nM SUR2A >1 μM	[20]
Activators
Diazoxide		SURl > SUR2	30–60 μM	[21,22]
Pinacidil		SUR2	˜1 μM	[21,23]
P1075		SUR2	≤50 nM	[21,24]
Levcromakalim		SUR2	-0.4–3 μM	[21,25]
NN414		SUR1	450 nM	[22]
VU0071063		SUR1	˜7 μM	[26]