Fig 6. Correlations between ADCC activity and antibody signal intensities as well as ELISA antibody titers.

Median cross clade signal intensities and ELISA antibody titers were stratified into two specific groups (< median and > median) and compared to %ADCC activity. Significant correlations were found between patient samples with high ADCC activity against HIV-1_SF162 and high median cross clade signal intensities (p = 0.004) (A) as well as high median cross clade ELISA titers (p = 0.004) (B). A clear trend towards higher ADCC activity against HIV-1_JR-FL infected cells was observed with higher antibody signals (C) or ELISA titers (D). No correlation was found between ADCC of SOSIP decorated cells and median cross clade signals (E) and ELISA titers (F).