Table 4. Hazard ratios for allograft failure with adjustment for competing risks in 2,902 subjects.
Without competing risk | With competing risk of cardiac death | With competing risks of cardiac & unknown death | |||||
---|---|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | ||
Model 1* | |||||||
Pre-transplant CV Risk Score§ | 1st tertile | 1.00 | 1.00 | 1.00 | |||
2nd tertile | 1.19 (0.89–1.60) | 0.237 | 1.16 (0.84–1.59) | 0.370 | 1.17 (0.86–1.61) | 0.320 | |
3rd tertile | 1.65 (1.22–2.23) | 0.001 | 1.54 (1.10–2.15) | 0.012 | 1.46 (1.05–2.03) | 0.025 | |
Model 2* | |||||||
Pre-transplant CV Risk Score (per 1 score increase) | 1.05 (1.02–1.07) | 0.001 | 1.04 (1.01–1.07) | 0.026 | 1.03 (1.01–1.06) | 0.029 | |
Model 3* | |||||||
Vascular disease | 2.51 (1.66–3.80) | <0.001 | 2.05 (1.25–3.38) | 0.005 | 2.19 (1.35–3.55) | 0.002 |
* In models 1–3, adjustments for recipient gender, induction therapy, donor age, donor type, recurrent glomerulonephritis, and biopsy-proven acute rejection were performed.
§ 1st tertile, 0–4 in men and 0–4 in women; 2nd tertile, 5–10 in men and 5–8 in women; 3rd tertile, ≥ 11 in men and ≥ 9 in women