Table 5. Incremental value of pre-transplant CV risk score or vascular disease over traditional risk factors for predicting allograft failure.
ROC analysis | NRI analysis | IDI analysis | ||||
---|---|---|---|---|---|---|
AUC (95% CI) | p | NRI (95% CI) | p | IDI (95% CI) | p | |
Model 1 (Traditional risk factors*) | 0.789 (0.762–0.815) | reference | reference | |||
Model 1 + Pre-transplant CV Risk Score | 0.791 (0.765–0.817) | 0.405 | 0.142 (0.055–0.228) | 0.001 | 0.003 (0.001–0.006) | 0.021 |
Model 1 + Vascular disease | 0.790 (0.764–0.817) | 0.576 | 0.097 (0.042–0.151) | 0.028 | 0.0028 (0.001–0.005) | 0.006 |
Model 1 + Pre-transplant CV Risk Score+ Vascular disease | 0.790 (0.764–0.817) | 0.576 | 0.128 (0.042–0.214) | 0.004 | 0.0046 (0.001–0.008) | 0.005 |
* Traditional risk factors of GF include recipient gender, induction therapy, donor age, donor type, recurrent glomerulonephritis, and biopsy-proven acute rejection. AUC, area under the curve; CI, confidence interval; IDI, integrated discrimination improvement; NRI, net reclassification improvement; ROC, receiver operating characteristic