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. 2016 Aug 8;11(8):e0160607. doi: 10.1371/journal.pone.0160607

Table 5. Incremental value of pre-transplant CV risk score or vascular disease over traditional risk factors for predicting allograft failure.

ROC analysis NRI analysis IDI analysis
AUC (95% CI) p NRI (95% CI) p IDI (95% CI) p
Model 1 (Traditional risk factors*) 0.789 (0.762–0.815) reference reference
Model 1 + Pre-transplant CV Risk Score 0.791 (0.765–0.817) 0.405 0.142 (0.055–0.228) 0.001 0.003 (0.001–0.006) 0.021
Model 1 + Vascular disease 0.790 (0.764–0.817) 0.576 0.097 (0.042–0.151) 0.028 0.0028 (0.001–0.005) 0.006
Model 1 + Pre-transplant CV Risk Score+ Vascular disease 0.790 (0.764–0.817) 0.576 0.128 (0.042–0.214) 0.004 0.0046 (0.001–0.008) 0.005

* Traditional risk factors of GF include recipient gender, induction therapy, donor age, donor type, recurrent glomerulonephritis, and biopsy-proven acute rejection. AUC, area under the curve; CI, confidence interval; IDI, integrated discrimination improvement; NRI, net reclassification improvement; ROC, receiver operating characteristic