Table 1.
Paraneoplastic syndromes with lung cancer
| Paraneoplastic syndromes with lung cancer | Frequently caused by |
|---|---|
| Endocrine syndrome | |
| Hypercalcemia | Squamous cell (mostly), adenocarcinoma, SCLC |
| SIADH | SCLC |
| Cushing’s syndrome | SCLC (mostly), carcinoid tumor of lung |
| Neurologic syndrome | |
| Lambert–Eaton syndrome | SCLC |
| Limbic encephalopathy | SCLC |
| Cerebellar degeneration | SCLC |
| Autonomic neuropathy | SCLC |
| Skeletal manifestations | |
| Digital clubbing | NSCLC (mostly adenocarcinoma) |
| Hypertrophic pulmonary osteoarthropathy | NSCLC (mostly adenocarcinoma) |
| Hematologic and vascular syndromes | |
| Anemia | NSCLC |
| Leukocytosis | NSCLC |
| Thrombocytosis | NSCLC |
| Hypercoagulable disorders | NSCLC (mostly adenocarcinoma) |
| Trousseau’s syndrome (migratory superficial thrombophlebitis) | |
| Deep venous thrombosis | |
| Disseminated intravascular coagulopathy | |
| Cutaneous manifestations | |
| Polymyositis/Dermatomyositis | SCLC |
| AN | NSCLC (mostly adenocarcinoma) |
| Hyperkeratosis of palms and soles | NSCLC (mostly squamous cell) |
Abbreviations: SCLC, small cell lung cancer; SIADH, syndrome of inappropriate antidiuretic hormone secretion; NSCLC, non-small-cell lung cancer; AN, acanthosis nigricans.