Table 3. Serological response to vaccination.
Median values for serum antibody titers taken prior to vaccination (day 0), at the time of boost (day 28), immediately prior to H. somni bacterial challenge (day 42) and immediately prior to euthanization (day 63). “R” is denoted for rank of gene or protein. The vaccine for group A (placebo/control group) did not contain antigens. The vaccine for groups B, C and D contained antigens (R2, R5, R8, R18, R27, R37), (R13, R15, R21, R24, R34, R36) and (R1, R4, R22, R23, R35) respectively.
| Antigen | Median values for serum antibody titers(vaccinated groups) | Median values for serum antibody titers(non-vaccinated group A) | ||||||
|---|---|---|---|---|---|---|---|---|
| Group B | Day 0 | Day 28 | Day 42 | Day 63 | Day 0 | Day 28 | Day 42 | Day 63 |
| R2 | 232 | 491 | 2069 | 2853 | 69 | 57 | 161 | 218 |
| R5 | 962 | 4272 | 14216 | 15670 | 525 | 608 | 772 | 372 |
| R8 | 662 | 4228 | 12056 | 14741 | 460 | 445 | 602 | 4101 |
| R18 | 36 | 913 | 3013 | 4237 | 87 | 44 | 72 | 8860 |
| R27 | 3538 | 20418 | 60688 | 45566 | 3201 | 3542 | 4116 | 5118 |
| R37 | 3675 | 30923 | 58009 | 44620 | 3433 | 3491 | 4286 | 8110 |
| Group C | ||||||||
| R13 | 893 | 3623 | 11537 | 11129 | 657 | 812 | 939 | 4433 |
| R15 | 252 | 450 | 2545 | 2512 | 153 | 131 | 223 | 759 |
| R21 | 1228 | 15817 | 49710 | 29344 | 2397 | 3040 | 3585 | 4913 |
| R24 | 2604 | 18543 | 63826 | 47868 | 3109 | 3724 | 4353 | 7871 |
| R34 | 160 | 557 | 1413 | 1367 | 55 | 97 | 232 | 551 |
| R36 | 1136 | 14571 | 48290 | 27734 | 1754 | 2876 | 3551 | 4732 |
| Group D | ||||||||
| R1 | 49 | 314 | 1293 | 1573 | 133 | 143 | 215 | 506 |
| R4 | 2106 | 16202 | 50635 | 47892 | 1472 | 2871 | 3505 | 5185 |
| R22 | 3159 | 18044 | 57298 | 49019 | 3205 | 3361 | 3789 | 4727 |
| R23 | 3291 | 18895 | 57180 | 58139 | 2621 | 3296 | 3606 | 5381 |
| R35 | 4 | 109 | 710 | 647 | 32 | 5 | 35 | 154 |