Figure 2.

Incremental contribution of genetic risk score (GRS) to coronary heart disease (CHD) discrimination in Afro-Caribbeans (n = 537). Predictions are based on logistic regression models incorporating traditional cardiovascular risk factors (TCRFs) (age, sex, hypercholesterolemia, diabetes, hypertension, and smoking) alone or with the addition of the nonweighted 14 single nucleotide polymorphism (SNP) GRSs. The area under the curve (AUC) measures the ability of the model to discriminate between individuals with CHD and those without CHD.