Table 1.

SNPs included in the genetic risk scores (GRS14 and GRS19) and their published estimates

SNP	Chromosome	Gene/locus	SNP location or amino acid change	Alleles	Published OR	Reference
Risk/reference
rs4341	17q23	ACE	Intergenic	G/C	1.01	Schunkert et al.16
rs662799∗	11q23	APOA5	Promoter Variant	G/A	1.1	CARDIoGRAMplusC4D Consortium et al.14
rs1042031	2p23-24	APOB	E4181K	A/G	1.01	CARDIoGRAMplusC4D Consortium et al.14
rs429358∗	19q13.2	APOE	C112R	C/T	1.25	Bennett et al.17
rs7412∗	19q13.2	APOE	C158R	C/T	1.06	Bennett et al.17
rs10757274∗	9p21	CDKN2A/CDKN2B	Intergenic	G/A	1.23	CARDIoGRAMplusC4D Consortium et al.14
rs599839∗	1p13.3	CELSR2/PSRC1/SORT1	Intergenic	A/G	1.11	CARDIoGRAMplusC4D Consortium et al.14
rs708272	16q21	CETP	Intronic	C/T	1.04	Schunkert et al.16
rs1746048∗	10q11.2	CXCL12	Intergenic	C/T	1.07	CARDIoGRAMplusC4D Consortium et al.14
rs7025486∗	9q33	DAB2IP	Intergenic	A/G	1.04	CARDIoGRAMplusC4D Consortium et al.14
rs10455872∗	6q26	LPA	Intergenic	G/A	1.32	Schunkert et al.16
rs3798220∗	6q26	LPA	I1891M	C/T	1.28	Schunkert et al.16
rs1801177∗	8p22	LPL	D36N	A/G	1.09	CARDIoGRAMplusC4D Consortium et al.14
rs328∗	8p22	LPL	S474X	C/G	1.1	CARDIoGRAMplusC4D Consortium et al.14
rs17465637∗	1q41	MIA3	Intergenic	C/A	1.14	Schunkert et al.16
rs9818870∗	3q23.3	MRAS	Intergenic	T/C	1.07	CARDIoGRAMplusC4D Consortium et al.14
rs1799983	7q35-36	NOS3	D298E	T/G	1.0	CARDIoGRAMplusC4D Consortium et al.14
rs11591147∗	1p32.3	PSCK9	R46L	G/T	1.39	Benn et al.18
rs17228212	15q22	SMAD3	Intergenic	C/T	1.01	CARDIoGRAMplusC4D Consortium et al.14

The APOA5 promoter variant has been shown to be functional.¹⁹ All SNPs were included in the 19-SNP gene score (GRS19).

OR, odds ratio; SNP, single nucleotide polymorphism.

^∗SNPs that were selected for the 14-SNP-GRS (GRS14) construction.