Table 3.
Risk allele frequencies of the 19 SNPs and GRSs in Afro-Caribbean controls compared with white controls
| SNP | Gene | Afro-Caribbeans without CHD (n = 359) |
Whites without CHD (n = 1214) |
P value |
|---|---|---|---|---|
| RAF | RAF | |||
| rs4341 | ACE | 0.6 | 0.52 | 8 × 10−3 |
| rs662799 | APOA5 | 0.13 | 0.06 | 1 × 10−5 |
| rs1042031 | APOB | 0.15 | 0.18 | 0.19 |
| rs429358 | APOE | 0.23 | 0.17 | 0.01 |
| rs7412 | APOE | 0.93 | 0.91 | 0.23 |
| rs10757274 | CDKN2A/CDKN2B | 0.21 | 0.48 | 8.19 × 10−20 |
| rs599839 | CELSR2/PSRC1/SORT1 | 0.25 | 0.78 | 3 × 10−77 |
| rs708272 | CETP | 0.76 | 0.56 | 1 × 10−11 |
| rs1746048 | C × CL12 | 0.53 | 0.86 | 1 × 10−40 |
| rs7025486 | DAB2IP | 0.32 | 0.26 | 0.03 |
| rs10455872 | LPA | 0.01 | 0.07 | 1 × 10−5 |
| rs3798220 | LPA | 0.01 | 0.02 | 0.21 |
| rs1801177 | LPL | 0.001 | 0.01 | NA |
| rs328 | LPL | 0.94 | 0.90 | 0.02 |
| rs17465637 | MIA3 | 0.24 | 0.71 | 2 × 10−57 |
| rs9818870 | MRAS | 0.08 | 0.16 | 1 × 10−4 |
| rs1799983 | NOS3 | 0.12 | 0.33 | 8 × 10−15 |
| rs11591147 | PSCK9 | 1.00 | 0.99 | NA |
| rs17228212 | SMAD3 | 0.12 | 0.31 | 9 × 10−13 |
| Nonweighted GRS19 (SD) | 13.17 (± 2.10) | 16.59 (± 2.20) | < 1 × 10−100 | |
| Nonweighted GRS14 (SD) | 9.69 (± 1.70) | 12.76 (± 1.69) | < 1 × 10−100 | |
For white participants, RAFs are reported from the NPHSII cohort.
CHD, coronary heart disease; GRS, genetic risk score; NA, not available; NPHSII, Second Northwick Park Heart Study; RAF, risk allele frequency; SD, standard deviation; SNP, single nucleotide polymorphism.