Table 4.

Association between cardiovascular risk factors and GRS with CHD in Afro-Caribbeans

Multivariate logistic regression for CHD
	OR	95% CI	P value
Age	1.06	(1.03-1.08)	< 1 × 10−5
Male sex	3.09	(1.84-5.19)	2 × 10−5
Hypertension	4.30	(2.49-7.26)	< 1 × 10−5
Diabetes	2.13	(1.23-3.68)	7 × 10−3
Hypercholesterolemia	3.45	(2.08-5.73)	< 1 × 10−5
Smoking	3.06	(1.64-5.71)	5 × 10−4
Nonweighted GRS19	1.40	(1.09-1.80)	8 × 10−3

ORs are expressed per 1 standard deviation change.

CHD, coronary heart disease; CI, confidence interval; GRS, genetic risk score; OR, odds ratio.