Table 6.

Predictive values of GRSs in Afro-Caribbeans and whites males after adjustment with TCRFs

	Afro-Caribbeans			Whites (NPHSII)
OR	95% CI	P value	OR	95% CI	P value
NW_GRS19	1.62	(1.16-2.27)	4 × 10−3	1.27	(1.06-1.51)	9 × 10−3
W_GRS19	1.32	(0.96-1.81)	0.08	1.33	(1.11-1.60)	2.3 × 10−3
NW_GRS14	1.42	(1.03-1.95)	0.03	1.40	(1.19-1.66)	5.3 × 10−5
W_GRS14	1.38	(1.01-1.88)	0.04	1.42	(1.20-1.67)	3.3 × 10−5

ORs are expressed per 1 standard deviation change and were calculated from model incorporating each GRS, age, hypertension, diabetes, hypercholesterolemia, and smoking in both ethnic groups. In the Afro-Caribbean sample, we considered only men (n = 271) because the NPHSII cohort included only men (n = 1360 for GRS19 and n = 1607 for GRS14).

CI, confidence interval; GRS, genetic risk score; NPHSII, Second Northwick Park Heart Study; NW, nonweighted; OR, odds ratio; W, weighted.