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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Expert Opin Ther Targets. 2016 Feb 11;20(7):869–883. doi: 10.1517/14728222.2016.1139084

Figure 1. A diagram of the human SCGB1A1 gene.

Figure 1

In A, the human CC16 (SCGB1A1) gene is localized in chromosome 11q12.3. The gene has 18,108 bases pairs and contains three exons and two introns. There are four Alu repeats including three in intron 1 and one in intron 2. B shows the promoter regions of the human SCGB1A1 gene which contains two binding regions. Region I (I) is located ~110 bp upstream and region II (II) is located around −220 bp upstream of the transcription initiation site. The region-I is the binding site for several transcription factors that are known to regulate CC16 expression: hepatocyte nuclear factors α and β (HNF-α/β), activation protein-1 (AP-1), and the transcription factor Octamer (Oct) and also for transcription factors that inhibit CC16 expression: chicken ovoalbumin upstream promoter transcription factors (COUP-TFs). Region-II binds transcription factors that enhance transcriptional activation of the gene when region I is activated, and also contains binding sites for HNFs.