. 2016 Apr 15;124(8):1241–1252. doi: 10.1289/EHP237

Table 2.

Top five up-regulated and top five down-regulated genes ranked by magnitude of fold change over control at 4 hr post-damage induction.^a

Outcome	BPA		KBrO₃		BPA + KBrO₃
Outcome	Gene	Fold change^b	Gene	Fold change	Gene	Fold change
Up-regulated	CCL20	60.370	GSTA5	195.423	IL18R1	150.272
	CXCL3	55.581	IL18R1	165.986	GSTA5	118.712
	Saa3	26.361	AREG	131.227	PTGS2	95.172
	HCAR2	25.405	DUSP2	92.477	AREG	84.638
	EGR4	23.721	EGR4	65.351	ATF3	81.490
Down-regulated	LGALS12	–10.284	KLF15	–56.007	TNS1	–41.975
	DSC1	–8.749	Cyp2d22	–35.115	Akr1b10	–39.628
	FRY	–5.689	IKZF2	–22.961	FZD2	–35.905
	HPGD	–4.937	BMF	–22.292	Cyp2d22	–35.268
	PLCH2	–4.768	Akr1b10	–21.197	KAT2B	–30.719
^aSamples treated with 150 μM BPA only were exposed for 5 hr; those treated with 20 mM KBrO₃ only were exposed for 1 hr, then medium was replaced for 3 hr; and samples co-exposed to 150 μM BPA were exposed for 1 hr, then exposed to 150 μM BPA + 20 mM of KBrO₃ for 1 hr, followed by exposure for 3 hr to 150 μM BPA only. ^bGene expression fold change was evaluated in comparison with untreated control with all p-values < 0.01.