Table 3.
Associations between maternal pregnancy triclosan levels and birth outcomes among newborn boys and girls from the Odense Child Cohort.
| TCS | Birth weight (g) | Birth length (cm) | Head circumference (cm) | Abdominal circumference (cm) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | β (95% CI) | p-Value | n | β (95% CI) | p-Value | n | β (95% CI) | p-Value | n | β (95% CI) | p-Value | |
| Boys | ||||||||||||
| TCS quartilea | ||||||||||||
| 1st | 69 | Reference | 69 | Reference | 69 | Reference | 68 | Reference | ||||
| 2nd | 66 | –62 (–199, 74) | 0.37 | 66 | 0.1 (–0.5, 0.7) | 0.83 | 66 | –0.2 (–0.7, 0.4) | 0.52 | 64 | –0.3 (–0.9, 0.3) | 0.33 |
| 3rd | 66 | 29 (–108, 166) | 0.68 | 65 | 0.7 (0.1, 1.3) | 0.03 | 64 | –0.3 (–0.9, 0.2) | 0.24 | 64 | –0.4 (–1.0, 0.2) | 0.22 |
| 4th | 66 | –81 (–218, 56) | 0.25 | 64 | 0.1 (–0.5, 0.8) | 0.65 | 65 | –0.7 (–1.2, –0.1) | 0.01 | 65 | –0.6 (–1.2, 0.0) | 0.07 |
| p-Trendb | 0.49 | 0.29 | 0.01 | 0.07 | ||||||||
| Continuousc | 267 | –5.2 (–18.5, 8.2) | 0.45 | 264 | 0.01 (–0.05, 0.07) | 0.70 | 264 | –0.06 (–0.11, –0.002) | 0.04 | 261 | –0.05 (–0.11, 0.01) | 0.09 |
| Girls | ||||||||||||
| TCS quartilea | ||||||||||||
| 1st | 60 | Reference | 59 | Reference | 59 | Reference | 59 | |||||
| 2nd | 60 | 50 (–90, 190) | 0.48 | 60 | –0.5 (–1.1, 0.1) | 0.11 | 60 | –0.4 (–0.9, 0.2) | 0.19 | 60 | 0.3 (–0.4, 0.9) | 0.47 |
| 3rd | 60 | 25 (–116, 167) | 0.72 | 60 | –0.4 (–1.0, 0.2) | 0.24 | 60 | –0.3 (–0.8, 0.2) | 0.28 | 59 | 0.1 (–0.6, 0.8) | 0.84 |
| 4th | 60 | 36 (–104, 176) | 0.62 | 60 | –0.2 (–0.8, 0.4) | 0.53 | 59 | –0.2 (–0.7, 0.3) | 0.49 | 59 | –0.03 (–0.7, 0.6) | 0.93 |
| p-Trendb | 0.71 | 0.66 | 0.56 | 0.81 | ||||||||
| Continuousc | 240 | 4.7 (–7.3, 17.0) | 0.43 | 239 | –0.004 (–0.06, 0.05) | 0.89 | 238 | –0.01 (–0.05, 0.04) | 0.70 | 237 | 0.00 (–0.06, 0.06) | 0.998 |
| TCS × Sex | ||||||||||||
| p-Interactiond | 507 | 0.39 | 503 | 0.57 | 502 | 0.24 | 498 | 0.27 | ||||
| Abbreviations: CI, confidence interval; LOD, level of detection; TCS, triclosan. All estimates are adjusted for gestational age, maternal smoking, parity and prepregnancy BMI. aMedian (range) for osmolality-adjusted TCS quartiles (nanograms/milliliter(osm)) in boys: 1st = < LOD (< LOD to < 0.24), 2nd = 0.53 (0.24 to < 0.97), 3rd = 1.69 (0.97 to < 3.24), 4th = 17.8 (3.24 to 1,702); in girls: 1st = < LOD (< LOD to < 0.247), 2nd = 0.50 (0.247 to < 1.05), 3rd = 2.03 (1.05 to < 4.21), 4th = 103.1 (4.21 to 2,350). bp-Value for trend across TCS quartiles. clog2-transformed TCS concentration. dp-Value for interaction [child sex × maternal urinary TCS levels (continuous log2-transformed TCS concentration)]. Median gestational week of maternal urine collection for boys: 28.7 (26.4–30.4) weeks; for girls: 28.7 (range 27.9–34.0) weeks. | ||||||||||||