Table 4.

Associations between maternal pregnancy TCS levels and AGDas (short AGD measure), AGDap (long AGD measure) and penile width in boys and AGDaf (short AGD measure) and AGDac (long AGD measure) in girls at 3 months of age from the Odense Child Cohort.

TCS quartilea	Boys									Girls
	AGDas (mm)			AGDap (mm)			Penile width (mm)			AGDaf (mm)			AGDac (mm)
	n	β (95% CI)	p-Value	n	β (95% CI)	p-Value	n	β (95% CI)	p-Value	n	β (95% CI)	p-Value	n	β (95% CI)	p-Value
1st	64	Reference		63	Reference		63	Reference		51	Reference		50	Reference
2nd	61	–0.9 (–2.8, 0.9)	0.33	60	0.3 (–1.7, 2.3)	0.77	59	0.0 (–0.4, 0.5)	0.81	40	–0.5 (–2.0, 1.0)	0.51	40	–0.6 (–2.4, 1.2)	0.54
3rd	62	–2.3 (–4.1, –0.4)	0.02	59	–1.2 (–3.3, 0.8)	0.24	62	–0.1 (–0.5, 0.3)	0.55	43	–0.4 (–1.8, 1.1)	0.59	43	0.1 (–1.6, 1.9)	0.87
4th	58	–1.3 (–3.1, 0.6)	0.19	54	–1.3 (–3.4, 0.8)	0.22	57	–0.2 (–0.6, 0.3)	0.44	44	–0.3 (–1.8, 1.1)	0.66	43	0.1 (–1.7, 1.8)	0.95
p-Trendb			0.08			0.11			0.32			0.69			0.79
Continuousc	245	–0.16 (–0.34, 0.02)	0.07	236	–0.20 (–0.39, 0.00)	0.05	241	–0.02 (–0.06, 0.02)	0.27	178	–0.02 (–0.15, 0.10)	0.72	176	0.01 (–0.15, 0.17)	0.89
Abbreviations: AGD, anogenital distance; AGDac, long AGD measure (girls); AGDaf, short AGD measure (girls); AGDap, long AGD measure (boys); AGDas, short AGD measure (boys); CI, confidence interval; TCS, triclosan. All estimates are adjusted for weight for age standard deviation score and post-conceptional age (gestational age at birth + age of the child at the AGD measurements, days). aMedian (range) for osmolality-adjusted TCS quartiles (nanograms/milliliter(osm)) in boys: 1st = < LOD (< LOD to < 0.24), 2nd = 0.53 (0.24 to < 0.97), 3rd = 1.69 (0.97 to < 3.24), 4th = 17.8 (3.24 to 1,702); in girls: 1st = < LOD (< LOD to < 0.247), 2nd = 0.50 (0.247 to < 1.05), 3rd = 2.03 (1.05 to < 4.21), 4th = 103.1 (4.21 to 2,350). bp-Value for trend across TCS quartiles. cLog2-transformed TCS concentration. Median age at AGD measurements for boys, 3.3 months (range 2.3–6.2 months); for girls, 3.3 months (range 2.3–6.7 months).