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. 2016 Jan 13;124(8):1214–1226. doi: 10.1289/ehp.1510352

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Venn diagrams comparing three main nuclear receptor commercial assays employed in ToxCast™. Phase II, release 2014 (Filer et al. 2014) assay datasets (gain AC₅₀ values) were obtained for five nuclear receptors: PPARγ, androgen receptor (AR), estrogen receptor (ER), farnesoid X receptor (FXR), and glucocorticoid receptor (GR). Three assays for each receptor were evaluated: Attagene (ATG) agonist assay (red), NovaScreen^® (NVS) direct binding assay (green), and NCGC/Tox21 GeneBLAzer^® agonist assay (blue). An additional diagram (top right) was created for PPARγ using NCGC/Tox21 antagonism assay. Chemicals scoring AC₅₀ ≤ 10 μM for each assay were incorporated in the Venn diagrams, which were created by BioVenn (Hulsen et al. 2008).