Table 2.
CpG loci identified as genome-wide significantly associated (Bonferroni p ≤ 0.05; p < 1 x 10–7) with placental arsenic levels following cell composition adjustment.
| Loci | Coefficienta | FDR q-value | Bon p-value | Chromosome | Position | Gene |
|---|---|---|---|---|---|---|
| cg01953134 | –0.0018 | 1.73E-07 | 1.73E-07 | 6 | 90348409 | LYRM2 |
| cg08640609 | –0.0012 | 5.98E-07 | 1.75E-06 | 1 | 7764642 | CAMTA1 |
| cg27642643 | –0.0032 | 5.98E-07 | 1.79E-06 | 6 | 90348450 | LYRM2 |
| cg11240327 | –0.0042 | 7.92E-07 | 3.17E-06 | 6 | 90348503 | LYRM2 |
| cg10392378 | –0.0026 | 1.32E-06 | 6.59E-06 | 6 | 90348606 | LYRM2 |
| cg21621759 | –0.0035 | 7.94E-06 | 4.76E-05 | 6 | 90348302 | LYRM2 |
| cg03200341 | –0.0023 | 8.87E-06 | 6.21E-05 | 6 | 90348309 | LYRM2 |
| cg21264329 | –0.0022 | 1.68E-05 | 1.34E-04 | 6 | 90348123 | LYRM2 |
| cg04843946 | –0.0061 | 1.73E-04 | 1.56E-03 | 6 | 90348009 | LYRM2 |
| cg02725437 | –0.0025 | 2.84E-04 | 2.84E-03 | 6 | 90348314 | LYRM2 |
| cg25719236 | –0.0024 | 5.60E-04 | 6.16E-03 | 6 | 90348382 | LYRM2 |
| cg01777586 | –0.0085 | 3.49E-03 | 4.19E-02 | 17 | 80163174 | CCDC57 |
| cg25430506 | –0.0038 | 3.68E-03 | 4.79E-02 | 6 | 90348385 | LYRM2 |
| Abbreviations: Bon, Bonferroni; FDR, false discovery rate. A complete list of loci may be found in Excel File Table S2. aThe difference in DNA methylation β value (0–1 scale) for every 1 unit (μg/kg) increase in placental arsenic. | ||||||