Table 3.
GO-term pathways (Gene Ontology Consortium 2015) significantly associated (Bonferroni < 0.05) with CpG loci with an altered effect estimate due to cellular proportion estimates.
| GO ID | Adjusted p-value* | Test estimate** | GO pathway |
|---|---|---|---|
| 9952 | 2.93E-32 | 3.267583 | Anterior/posterior pattern specification |
| 45944 | 1.23E-24 | 1.620397 | Positive regulation of transcription from RNA polymerase II promoter |
| 1764 | 8.85E-20 | 2.619747 | Neuron migration |
| 8045 | 3.16E-18 | 4.867233 | Motor neuron axon guidance |
| 48704 | 3.32E-17 | 3.356625 | Embryonic skeletal system morphogenesis |
| 45666 | 9.08E-17 | 2.780646 | Positive regulation of neuron differentiation |
| 7268 | 5.81E-16 | 1.74411 | Synaptic transmission |
| 122 | 6.65E-16 | 1.555492 | Negative regulation of transcription from RNA polymerase II promoter |
| 21884 | 9.60E-16 | 7.876803 | Forebrain neuron development |
| 7389 | 2.01E-15 | 3.83696 | Pattern specification process |
| 31018 | 7.34E-15 | 3.799679 | Endocrine pancreas development |
| 35115 | 2.13E-14 | 3.351906 | Embryonic forelimb morphogenesis |
| 44267 | 6.43E-14 | 0.3915227 | Cellular protein metabolic process |
| 21983 | 7.84E-14 | 3.640762 | Pituitary gland development |
| 1657 | 9.08E-14 | 3.162291 | Ureteric bud development |
| 21913 | 1.29E-13 | 7.137178 | Regulation of transcription involved in ventral spinal cord interneuron specification |
| 21912 | 1.36E-13 | 8.044255 | Regulation of transcription involved in spinal cord motor neuron fate specification |
| 9725 | 1.36E-13 | 3.760404 | Response to hormone |
| 6351 | 1.78E-13 | 1.351092 | Transcription, DNA-templated |
| 21797 | 2.49E-12 | 5.640727 | Forebrain anterior/posterior pattern specification |
| *Adjusted Bonferroni p-value to account for multiple comparisons. **χ2MH. | |||