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. 2016 Aug 4;10:2499–2506. doi: 10.2147/DDDT.S110742

Table 2.

Pharmacokinetic parameters of the two formulations

Parameter Formulations
Injection Microspheres
t½ (hours) 1.79±0.65 9.13±3.32
Cmax(ng/mL) 856.5±121.4 569.4±126.3*
AUC0–t(ng⋅h/mL) 5,439.6±541.7 23,210.2±2,315.4*
AUC0–∞(ng⋅h/mL) 5,864.9±598.2 25,265.6±2,448.6*
CL (L/h) 8.26±1.37 2.14±0.71*

Note:

*

P<0.05, RPC injection vs microspheres.

Abbreviations: AUC, area under the concentration–time curve; CL, clearance; Cmax, maximum observed concentration; RPC, ropivacaine; t½, elimination half-life.