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Kinetics of MT release from niosomal film and dispersion according to different kinetic models
| Formulation | Correlation coefficient (R2)*
|
(n)* Korsmeyer–Peppas equation | |||
|---|---|---|---|---|---|
| Zero order | First order | Higuchi diffusion | Peppas | ||
| Niosomal dispersion (N4) | 0.9798±0.012 | 0.9488±0.019 | 0.9925±0.018 | 0.9735±0.017 | 0.481±0.008 |
| Niosomal film (N4F6) | 0.9526±0.015 | 0.91852±0.021 | 0.9945±0.021 | 0.9793±0.015 | 0.476±0.012 |
Note:
Mean ± SD (n=3).
Abbreviations: MT, metoprolol tartarate; SD, standard deviation.
