Table 5.
Physicochemical evaluation of the selected fast dissolving film formulations during stability study
| Formula code
|
Fast dissolving film (F6)
|
Fast dissolving niosomal film (N4F6)
|
||||
|---|---|---|---|---|---|---|
| Time (days) | Zero | 60 (room temperature) | 60 (40°C) | Zero | 60 (room temperature) | 60 (40°C) |
| Weight (mg)* | 25.53±2.18 | 27.53±1.82 | 26.53±2.68 | 39.53±3.5 | 41.23±4.2 | 42.9±5.3 |
| Surface pH* | 7.2±0.15 | 7.1±0.12 | 7.2±0.11 | 6.9±0.2 | 6.8±0.3 | 6.9±0.18 |
| Folding endurance(number of folds)* | 229±18 | 225±22 | 235±16 | 220±21 | 221±17 | 226±23 |
| Disintegration time (seconds)* | 38.33±7.78 | 39.5±5.18 | 34.33±5.22 | 40.21±4.78 | 42.33±3.52 | 39.53±5.18 |
| Particle size (nm)* | – | – | – | 953.4±181.3 | 972.5±150.8 | 986.4±191.6 |
| Zeta potential (mV)* | – | – | – | −51±5.30 | −48±6.30 | −46±4.30 |
Notes:
*
Mean ± SD (n=3). “–” indicates no data.
Abbreviation: SD, standard deviation.