Table 1.
Mean hydrodynamic diameter and PDI of NLC, M-NLC, NLC-RFB, and M-NLC-RFB formulations
| Formulation | Mean hydrodynamic diameter (nm) | Polydispersity index (PDI) |
|---|---|---|
| NLC | 175±3 | 0.21±0.02 |
| M-NLC | 198±2a | 0.12±0.01a |
| NLC-RFB | 180±2 | 0.12±0.02b |
| M-NLC-RFB | 213±2a,c,d | 0.12±0.02a |
Notes: All values represent the mean ± standard deviation (n=3).
a
Statistically different (P<0.05) between NLCs and conjugated formulations.
b
Statistically different (P<0.05) between unloaded and loaded NLCs.
c
Statistically different (P<0.05) from M-NLC, between conjugated and unloaded formulations.
c
Statistically different (P<0.05) between unloaded conjugated NLCs and RFB loaded conjugated NLCs.
d
Statistically different (P<0.05) between loaded NLCs nonconjugated and loaded NLCs conjugated.
Abbreviations: PDI, polydispersity index; NLC, nanostructured lipid carrier; M, mannose; RFB, rifabutin.