Table 3.
Clinical characteristics of lean women from the PCOS with metformin group (1) at the beginning of the study and after 6 months metformin therapy
| Parameter | PCOS with metformin group n=15 (beginning of the study) | PCOS with metformin group n=15 (after 6 months metformin therapy) | Mean difference in parameters between 6 months and baseline in PCOS with metformin group | P-value |
|---|---|---|---|---|
| Weight (kg) | 60.33±3.5 | 59.67±3.46 | −0.67±1.54 | 0.12 |
| BMI (kg/m2) | 21.19±1.27 | 20.95±1.23 | −0.24±0.54 | 0.11 |
| FT3 (pmol/L) | 4.41±0.49 | 4.51±0.76 | 0.1±0.52 | 0.46 |
| TSH (IU/mL) | 1.99±0.62 | 1.98±0.57 | −0.01±0.03 | 0.12 |
| FT4 (pmol/L) | 13.01±2.2 | 13.2±1.7 | 0.09±0.67 | 0.63 |
| Prolactin (μIU/mL) | 243.9±87.18 | 239.67±85.17 | −4.27±23.62 | 0.49 |
| Cortisol-0800 hours (μm/dL) | 21.5±6.82 | 19.8±5.08 | −1.7±2.65 | 0.45 |
| Cortisol-1700 hours (μm/dL) | 11.3±4.48 | 10.9±4.34 | −0.4±2.12 | 0.33 |
| Estradiol (pmol/L) | 270.8±113.7 | 270.33±98.42 | −0.47±31.3 | 0.96 |
| LH (mIU/mL) | 11.46±2.74 | 5.55±1.51 | −5.91±1.95 | <0.001 |
| FSH (mIU/mL) | 6.87±1.08 | 6.79±1.04 | −0.08±0.96 | 0.39 |
| Testosterone (nmol/L) | 2.51±0.34 | 1.8±0.29 | −0.71±0.37 | <0.001 |
| SHBG (nmol/L) | 37.59±6.33 | 46.7±4.75 | 9.13±6.51 | <0.001 |
| FAI | 6.97±1.47 | 3.91±0.73 | −3.06±1.65 | <0.001 |
| Glucose 0′ (mmol/L) | 4.8±0.6 | 4.67±0.34 | −0.13±0.28 | 0.47 |
| Glucose 60′ (mmol/L) | 5.5±1.44 | 5.2±0.1.23 | −0.3±0.63 | 0.54 |
| Glucose 120′ (mmol/L) | 5.1±0.92 | 5.0±0.87 | −0.1±0.43 | 0.67 |
| Insulin 0′ (μU/mL) | 14.4±5.49 | 10.2±3.45 | −4.4±2.12 | <0.001 |
| Insulin 60′ (μU/mL) | 83.8±32.26 | 50.2±28.97 | −33.6±14.89 | <0.001 |
| Insulin 120′ (μU/mL) | 78.2±35.48 | 43.87±21.23 | −34.33±10.3 | <0.001 |
| β-Endorphins (pg/mL) | 16.22±2.04 | 15.46±1.82 | −0.76±1.93 | 0.15 |
| PPT deltoid muscle (kg/cm2) | 9.56±1 | 14.37±0.94 | 4.81±0.88 | <0.001 |
| PPT trapezius muscle (kg/cm2) | 7.96±0.98 | 13.67±0.76 | 5.71±1.16 | <0.001 |
Notes: Data are presented as mean ± SD. Analysis was carried out using t-test for dependent samples. Significance level <0.05.
Abbreviations: PCOS, polycystic ovary syndrome; BMI, body mass index; FT3, triiodothyronine; TSH, thyroid-stimulating hormone; FT4, thyroxin; SHBG, sex hormone-binding globulin; FAI, free androgen index; LH, luteinizing hormone; FSH, follicle-stimulating hormone; PPT, pressure pain threshold.